CAFFERTY LAB

Functional neuroplasticity

  1. Wang X, Zhou T, Maynard GD, Terse PS, Cafferty WB, Kocsis JD, Strittmatter SM. Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury. Brain. 2020 Jun 1;143(6):1697-1713. doi: 10.1093/brain/awaa116. PubMed [citation] PMID: 32375169

  2. Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM. Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma. J Neurosci. 2019 Apr 24;39(17):3204-3216. doi: 10.1523/JNEUROSCI.2996-18.2019. Epub 2019 Feb 25. PubMed [citation] PMID: 30804090, PMCID: PMC6788813

  3. Dell'Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM. Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit. Nat Commun. 2018 Aug 24;9(1):3419. doi: 10.1038/s41467-018-05844-8. PubMed [citation] PMID: 30143638, PMCID: PMC6109094

  4. Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Rep. 2018 Jul 3;24(1):269. doi: 10.1016/j.celrep.2018.06.079. No abstract available. PubMed [citation] PMID: 29972787

  5. Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM. The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury. Sci Signal. 2018 Apr 3;11(524). pii: eaao4180. doi: 10.1126/scisignal.aao4180. PubMed [citation] PMID: 29615517, PMCID: PMC6179440

  6. Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ. Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Rep. 2017 Mar 14;18(11):2687-2701. doi: 10.1016/j.celrep.2017.02.058. PubMed [citation] PMID: 28297672, PMCID: PMC5389739

  7. Fink KL, Cafferty WB. Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. Neurotherapeutics. 2016 Apr;13(2):370-81. doi: 10.1007/s13311-016-0422-x. Review. PubMed [citation] PMID: 26846379, PMCID: PMC4824020

  8. Fink KL, Strittmatter SM, Cafferty WB. Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice. J Neurosci. 2015 Nov 18;35(46):15403-18. doi: 10.1523/JNEUROSCI.3165-15.2015. PubMed [citation] PMID: 26586827, PMCID: PMC4649010

  9. Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM. Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. J Neurosci. 2015 Jul 22;35(29):10429-39. doi: 10.1523/JNEUROSCI.1718-15.2015. PubMed [citation] PMID: 26203138, PMCID: PMC4510284

  10. Siegel CS, Fink KL, Strittmatter SM, Cafferty WB. Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury. J Neurosci. 2015 Jan 28;35(4):1443-57. doi: 10.1523/JNEUROSCI.3713-14.2015. PubMed [citation] PMID: 25632122, PMCID: PMC4308593

  11. Wang X, Yigitkanli K, Kim CY, Sekine-Komo T, Wirak D, Frieden E, Bhargava A, Maynard G, Cafferty WB, Strittmatter SM. Human NgR-Fc decoy protein via lumbar intrathecal bolus administration enhances recovery from rat spinal cord contusion. J Neurotrauma. 2014 Dec 15;31(24):1955-66. doi: 10.1089/neu.2014.3355. Epub 2014 Oct 16. PubMed [citation] PMID: 24964223, PMCID: PMC4245872

  12. Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM. Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery. J Neurotrauma. 2014 Aug 1;31(15):1362-73. doi: 10.1089/neu.2013.3238. Epub 2014 Jul 8. PubMed [citation] PMID: 24779685, PMCID: PMC4120934

  13. Harel NY, Yigitkanli K, Fu Y, Cafferty WB, Strittmatter SM. Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion. Brain Res. 2013 Nov 13;1538:17-25. doi: 10.1016/j.brainres.2013.07.012. Epub 2013 Sep 18. PubMed [citation] PMID: 24055330, PMCID: PMC3873870

  14. Akbik FV, Bhagat SM, Patel PR, Cafferty WB, Strittmatter SM. Anatomical plasticity of adult brain is titrated by Nogo Receptor 1. Neuron. 2013 Mar 6;77(5):859-66. doi: 10.1016/j.neuron.2012.12.027. Erratum in: Neuron. 2014 Jun 4;82(5):1184-5. PubMed [citation] PMID: 23473316, PMCID: PMC3594793

  15. Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB, Strittmatter SM. Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Exp Neurol. 2012 Sep;237(1):55-69. doi: 10.1016/j.expneurol.2012.06.009. Epub 2012 Jun 21. PubMed [citation] PMID: 22728374, PMCID: PMC3418451

  16. Shim SO, Cafferty WB, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Mol Cell Neurosci. 2012 Jun;50(2):193-200. doi: 10.1016/j.mcn.2012.04.007. Epub 2012 Apr 26. PubMed [citation] PMID: 22564823, PMCID: PMC3383336

  17. Duffy P, Wang X, Siegel CS, Tu N, Henkemeyer M, Cafferty WB, Strittmatter SM. Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5063-8. doi: 10.1073/pnas.1113953109. Epub 2012 Mar 12. Erratum in: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5905. Seigel, Chad S [corrected to Siegel, Chad S]. PubMed [citation] PMID: 22411787, PMCID: PMC3323955

  18. Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB, Strittmatter SM. Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov;70(5):805-21. doi: 10.1002/ana.22527. PubMed [citation] PMID: 22162062, PMCID: PMC3238798

  19. Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity. Exp Neurol. 2012 May;235(1):43-52. doi: 10.1016/j.expneurol.2011.06.006. Epub 2011 Jun 15. Review. PubMed [citation] PMID: 21699896, PMCID: PMC3189418

  20. Cafferty WB, Duffy P, Huebner E, Strittmatter SM. MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. J Neurosci. 2010 May 19;30(20):6825-37. doi: 10.1523/JNEUROSCI.6239-09.2010. PubMed [citation] PMID: 20484625, PMCID: PMC2883258

  21. Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty WB, Strittmatter SM. Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. J Neurosci. 2009 Dec 2;29(48):15266-76. doi: 10.1523/JNEUROSCI.4650-09.2009. PubMed [citation] PMID: 19955379, PMCID: PMC2855556

  22. Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-mediated plasticity of spinal sensory function. J Neurosci. 2008 Nov 12;28(46):11998-2009. doi: 10.1523/JNEUROSCI.3877-08.2008. PubMed [citation] PMID: 19005065, PMCID: PMC3844838

  23. Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci. 2008 May;31(5):215-20. doi: 10.1016/j.tins.2008.02.004. Epub 2008 Apr 7. Review. PubMed [citation] PMID: 18395807, PMCID: PMC2678051

  24. Cafferty WB, Kim JE, Lee JK, Strittmatter SM. Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron. 2007 Apr 19;54(2):195-9. No abstract available. PubMed [citation] PMID: 17442242, PMCID: PMC2848952

  25. Cafferty WB, Yang SH, Duffy PJ, Li S, Strittmatter SM. Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans. J Neurosci. 2007 Feb 28;27(9):2176-85. PubMed [citation] PMID: 17329414, PMCID: PMC2848955

  26. Cafferty WB, Strittmatter SM. The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth. J Neurosci. 2006 Nov 22;26(47):12242-50. PubMed [citation] PMID: 17122049, PMCID: PMC2848954

  27. McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp Neurol. 2005 Apr;192(2):444-62. Review. PubMed [citation] PMID: 15755561

  28. Liu BP, Cafferty WB, Budel SO, Strittmatter SM. Extracellular regulators of axonal growth in the adult central nervous system. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1593-610. Review. PubMed [citation] PMID: 16939977, PMCID: PMC1664666

  29. Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB. Regulation of neuropilin 1 by spinal cord injury in adult rats. Mol Cell Neurosci. 2005 Mar;28(3):475-84. PubMed [citation] PMID: 15737738

  30. Qiu J, Cafferty WB, McMahon SB, Thompson SW. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J Neurosci. 2005 Feb 16;25(7):1645-53. PubMed [citation] PMID: 15716400, PMCID: PMC6725934

  31. McMahon SB, Cafferty WB. Neurotrophic influences on neuropathic pain. Novartis Found Symp. 2004;261:68-92; discussion 92-102, 149-54. Review. PubMed [citation] PMID: 15469045

  32. Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci. 2004 May 5;24(18):4432-43. PubMed [citation] PMID: 15128857, PMCID: PMC6729445

  33. Gardiner NJ, Cafferty WB, Slack SE, Thompson SW. Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury. J Neurochem. 2002 Oct;83(1):100-9. PubMed [citation] PMID: 12358733

  34. Cafferty WB, Gardiner NJ, Gavazzi I, Powell J, McMahon SB, Heath JK, Munson J, Cohen J, Thompson SW. Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci. 2001 Sep 15;21(18):7161-70. PubMed [citation] PMID: 11549727, PMCID: PMC6762988

  35. Kerr BJ, Cafferty WB, Gupta YK, Bacon A, Wynick D, McMahon SB, Thompson SW. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. Eur J Neurosci. 2000 Mar;12(3):793-802. PubMed [citation] PMID: 10762308